KMID : 0359920090280010082
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Korean Journal of Nephrology 2009 Volume.28 No. 1 p.82 ~ p.87
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A Case of Kaposi¡¯s Sarcoma Improved by Sirolimus Treatment in the Kidney Transplant Recipient
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Lee Seung-Min
Park So-Yeon Kim Soo-Jin Song Young-Soo Song Hun-Ho Lee Sam-Uel Nam Eun-Sook Oh Ji-Eun
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Abstract
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The incidence of Kaposi¡¯s sarcoma (KS) increases in kidney transplant recipients who had the immunosuppressive therapy. The usual treatment of KS is to reduce the dosage of immunosuppressive agents, with chemotherapy and/or radiotherapy. Several studies have recently demonstrated that the conversion to proliferation signal inhibitors (PSIs) from calcineurin inhibitors (CNI) leads to the remission of some post-transplant tumors such as KS. PSIs were well tolerated with stable renal function and no episode of acute rejection was reported. On the basis of these findings, we report a case of Kaposi¡¯s sarcoma in the kidney transplant patient, who had multiple lymphadenopathy and hepatic involvement without skin lesions. This patient responded well to the change of the immunosuppressive treatment from cyclosporine to sirolimus, one of PSIs.
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KEYWORD
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Kaposi¡¯s sarcoma, Kidney transplantition, Sirolimus
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